Investigating how certain immune cells in the uterus affect pregnancy outcomes.
Functions for novel IL-15-responsive macrophages in the uterus during pregnancy
This study is looking at special immune cells in the uterus during pregnancy to see how they affect the health of both mothers and babies, especially when things don't go as planned, and it's aimed at helping us learn more about how the immune system works during pregnancy.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10986980 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of novel IL-15-responsive macrophages in the uterus during pregnancy. By examining how these immune cells function, the study aims to uncover their impact on maternal and fetal health, particularly in relation to adverse pregnancy outcomes. The approach involves advanced techniques in immunology and genetics, including next-generation sequencing, to analyze immune responses in pregnant individuals. This research is designed to enhance our understanding of reproductive immunology and its implications for pregnancy.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant individuals or those planning to become pregnant, particularly those with a history of pregnancy complications.
Not a fit: Patients who are not pregnant or do not plan to become pregnant may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing adverse pregnancy outcomes and enhancing maternal-fetal health.
How similar studies have performed: While the specific focus on IL-15-responsive macrophages in pregnancy is novel, related research in reproductive immunology has shown promising results in understanding immune responses during pregnancy.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Gordon, Scott Michael — Children's Hosp of Philadelphia
- Study coordinator: Gordon, Scott Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.