Investigating how certain immune cells develop in the thymus
Official title: Establishing a lineage tracing system for studying thymus-derived innate lymphoid cells
Funded at Oklahoma Medical Research Foundation · NIH-10795900 · Data updated 2026-11-12
This study is looking at how certain immune cells, called innate lymphoid cells, develop and move around the body, which could help us understand their role in fighting diseases.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | March 1, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $85,250 |
| NIH project number | 5R03AI175661-02 |
| Project ID | NIH-10795900 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting the immune system or those undergoing treatments that impact immune cell function.
✕Less likely to help
Patients with stable immune conditions or those not requiring immune modulation may not benefit from this research.
What this research studies
This research focuses on understanding the development of innate lymphoid cells (ILCs) that originate from the thymus. By utilizing advanced techniques like single cell RNA sequencing, the researchers aim to trace the lineage of these immune cells and determine how they migrate to different tissues in the body. The study will involve creating a specific genetic marker to label these cells, allowing for detailed tracking and analysis of their development and function. This could provide insights into the role of ILCs in immune responses and potential implications for various diseases.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of immune cell development and lead to improved treatments for immune-related conditions.
How similar studies have gone: While the specific lineage tracing approach may be novel, previous research has shown promising results in understanding immune cell development using similar methodologies.
Where this research is happening
-
Oklahoma Medical Research Foundation
Oklahoma City, United States Active
Researchers
- Principal investigator: Sun, Xiao-Hong — Oklahoma Medical Research Foundation
- Study coordinator: Sun, Xiao-Hong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.