Investigating how certain immune cells contribute to heart failure
Cardiac Macrophages as Disease Drivers in Chronic Ischemic Heart Failure
This study is looking at how certain immune cells called macrophages affect heart health in people with chronic ischemic heart failure, with the hope of finding new ways to help improve heart function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10814166 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of specific immune cells, known as macrophages, in the progression of chronic ischemic heart failure. It aims to explore how these macrophages, which can grow independently of blood cells, contribute to heart tissue damage and remodeling. By using advanced techniques like flow cytometry and single-cell RNA sequencing, the study will analyze the characteristics and behaviors of these macrophages in the heart. The findings could lead to new therapeutic strategies targeting these immune cells to improve heart function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic ischemic heart failure.
Not a fit: Patients with heart failure caused by non-ischemic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that slow down or reverse heart failure progression.
How similar studies have performed: Previous research has shown promising results in targeting immune cells for heart disease treatment, suggesting potential success for this approach.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Prabhu, Sumanth D — Washington University
- Study coordinator: Prabhu, Sumanth D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.