Investigating how certain immune cells contribute to eye diseases
Proangiogenic M2-type macrophages and choroidal neovascularization
This study is looking at how certain immune cells in the eye might help cause a condition called choroidal neovascularization (CNV), which is linked to age-related macular degeneration (AMD), and it hopes to find new ways to slow down this process for people who have AMD.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10893015 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of proangiogenic M2-type macrophages in the development of choroidal neovascularization (CNV), a condition associated with age-related macular degeneration (AMD). The study examines how these immune cells, which can promote blood vessel growth, accumulate in the eyes of patients with CNV and how their activity can be influenced by various factors. By exploring the signaling mechanisms that lead to the polarization of macrophages, the research aims to identify potential therapeutic targets to inhibit the progression of CNV in affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with neovascular age-related macular degeneration (AMD).
Not a fit: Patients with other forms of macular degeneration or those without any retinal diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively slow or prevent vision loss in patients with neovascular AMD.
How similar studies have performed: Previous research has shown promising results in targeting macrophage polarization to treat inflammatory conditions, suggesting that this approach may also be effective for CNV.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Marneros, Alexander Georg — Massachusetts General Hospital
- Study coordinator: Marneros, Alexander Georg
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.