Investigating how certain immune cells contribute to asthma in veterans exposed to combat conditions
Targeting pathogenic innate lymphoid cells in airway disease
This study is looking at how certain immune cells might contribute to asthma in veterans who have been deployed to combat zones, especially after being exposed to things like burn pits and dust storms, to help find better treatments for those affected.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA San Diego Healthcare System NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project ID | NIH-10922648 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of innate lymphoid cells in the development of asthma among military personnel who have been deployed to combat zones. By analyzing the effects of environmental exposures, such as burn pits and dust storms, on these immune cells, the study aims to uncover mechanisms that lead to airway inflammation and hyperreactivity. Using a mouse model, researchers will simulate exposure to harmful substances and assess the resulting airway responses, which could provide insights into new treatment strategies for affected veterans.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include veterans who have been deployed to Iraq or Afghanistan and are experiencing new-onset asthma or respiratory issues.
Not a fit: Patients who have not been deployed to combat zones or do not have asthma or related respiratory conditions may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for asthma and related respiratory conditions in veterans and potentially other populations exposed to similar environmental factors.
How similar studies have performed: Previous research has indicated a link between environmental exposures in combat zones and increased asthma incidence, suggesting that this study builds on established findings rather than exploring a completely novel area.
Where this research is happening
San Diego, United States
- VA San Diego Healthcare System — San Diego, United States (Active)
Researchers
- Principal investigator: Doherty, Taylor a — VA San Diego Healthcare System
- Study coordinator: Doherty, Taylor a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.