Investigating how certain HIV medications affect cell health
Anti-HIV NRTIs and the lysosomal toxicity
This study is looking at how certain HIV medications can sometimes harm cells and is trying to find ways to make these drugs safer while still working well, so people with HIV can have better treatment experiences.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10890043 on NIH RePORTER |
What this research studies
This research focuses on understanding the adverse effects of nucleoside reverse transcriptase inhibitors (NRTIs), which are commonly used to treat HIV. The study aims to explore how these medications can cause toxicity in cells, particularly through the role of a transporter protein called ENT3. By examining ways to reduce these toxic effects while maintaining the effectiveness of the drugs, the research seeks to improve patient compliance and overall treatment outcomes for those living with HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are currently undergoing treatment with NRTIs for HIV.
Not a fit: Patients who are not on NRTI therapy or those with other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer HIV treatments with fewer side effects, improving the quality of life for patients.
How similar studies have performed: Previous research has shown that addressing drug toxicity through targeted mechanisms can lead to improved patient outcomes, suggesting potential success for this approach.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Govindarajan, Rajgopal — Ohio State University
- Study coordinator: Govindarajan, Rajgopal
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.