Investigating how certain genetic elements contribute to Alzheimer's disease and related dementias
Defining molecular contributions of LINE-1 retrotransposons to AD / ADRD
['FUNDING_R01'] · ROCKEFELLER UNIVERSITY · NIH-11089296
This study is looking at how certain genetic elements might play a role in the development of Alzheimer's and related dementias as we age, with the hope of finding new ways to treat or prevent these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ROCKEFELLER UNIVERSITY (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11089296 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of LINE-1 retrotransposons in the development of Alzheimer's Disease (AD) and related dementias (ADRDs). It explores how these genetic elements become dysregulated with aging and may contribute to cellular senescence, a process where cells stop dividing and accumulate, leading to neurodegeneration. By studying the mechanisms involved, the research aims to uncover potential pathways that could be targeted for therapeutic interventions. Patients may benefit from insights that could lead to new treatments or preventive strategies for AD and ADRD.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults who are experiencing cognitive decline or have been diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with early-onset dementia or those without any cognitive impairment may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that slow down or prevent the progression of Alzheimer's disease and related dementias.
How similar studies have performed: Other research has shown promising results in understanding the role of cellular senescence in neurodegeneration, indicating that this approach has potential for significant advancements.
Where this research is happening
NEW YORK, UNITED STATES
- ROCKEFELLER UNIVERSITY — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LACAVA, JOHN — ROCKEFELLER UNIVERSITY
- Study coordinator: LACAVA, JOHN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: age associated disease, age associated disorder, age associated neurodegenerative disease, age associated neurodegenerative disorder