Investigating how certain genetic elements affect cancer linked to HIV.
(PQ#2) Transposable element-mediated gene regulation in KSHV-associated cancer
['FUNDING_R01'] · VANDERBILT UNIVERSITY MEDICAL CENTER · NIH-10804622
This study is looking at how certain genetic elements affect cancer-related genes in people with HIV, especially those with Kaposi's sarcoma and primary effusion lymphoma, to find new ways to treat these cancers.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-10804622 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of transposable elements in the regulation of genes associated with cancers that occur in individuals living with HIV, particularly Kaposi's sarcoma and primary effusion lymphoma. By examining how these genetic sequences influence cellular behavior during the infection by Kaposi's sarcoma-associated herpesvirus (KSHV), the research aims to uncover mechanisms that contribute to tumor development. The study employs advanced genetic analysis techniques to explore the interactions between KSHV and the host's cellular machinery, which may lead to new therapeutic targets for treating these malignancies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are at risk for or diagnosed with Kaposi's sarcoma or primary effusion lymphoma.
Not a fit: Patients who do not have HIV or those without any associated malignancies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cancers associated with HIV, improving outcomes for affected patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of genetic elements in cancer, suggesting that this approach may yield valuable insights.
Where this research is happening
NASHVILLE, UNITED STATES
- VANDERBILT UNIVERSITY MEDICAL CENTER — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KARIJOLICH, JOHN — VANDERBILT UNIVERSITY MEDICAL CENTER
- Study coordinator: KARIJOLICH, JOHN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immunodeficiency Syndrome, Cancers