Investigating how certain genes on chromosome 1q affect melanoma spread and progression
Chromosome 1q ceRNAs in Melanoma Progression and Metastasis
This study is looking at how certain genes on chromosome 1q might affect the growth and spread of melanoma, a serious skin cancer, to help find new ways to understand and treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11086119 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of specific genes located on chromosome 1q in the progression and spread of melanoma, a serious skin cancer. It explores how these genes, known as competitive endogenous RNAs (ceRNAs), may influence cancer development by regulating other important molecules called microRNAs. By studying the genetic changes and expression patterns in melanoma cells, the research aims to uncover new mechanisms that drive metastasis, which is a leading cause of death in melanoma patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with melanoma, particularly those with advanced stages of the disease.
Not a fit: Patients with non-melanoma skin cancers or those without metastatic disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting the mechanisms of melanoma metastasis, potentially improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding the role of ceRNAs in cancer progression, indicating that this approach may yield valuable insights.
Where this research is happening
Tampa, United States
- H. Lee Moffitt Cancer Ctr & Res Inst — Tampa, United States (Active)
Researchers
- Principal investigator: Karreth, Florian — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Karreth, Florian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.