Investigating how certain genes may protect against Alzheimer's disease in the brain's dentate gyrus.
Transcriptional Dysfunction in Dentate Gyrus Cell Types: Roles of Retinoic Acid Responsive Genes in Protection Against Alzheimer's Disease Pathogenesis
This study is looking at how certain genes in a part of the brain linked to Alzheimer's disease respond to a vitamin A-related substance, and it hopes to find ways to protect the brain from damage that can lead to memory problems, which could help people with early Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Tech University Health Scis Center NIH-funded |
| Lab location | 1 site (Lubbock, United States) |
| Project ID | NIH-11001967 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of retinoic acid responsive genes in the dentate gyrus, a part of the brain affected in Alzheimer's disease. It examines how oxidative stress and mitochondrial dysfunction contribute to cognitive decline in early Alzheimer's stages. By studying the effects of all-trans retinoic acid, an antioxidant, the research aims to identify potential protective mechanisms against Alzheimer's pathology. Patients may benefit from insights that could lead to new therapeutic strategies targeting these pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or in the early stages of Alzheimer's disease.
Not a fit: Patients with advanced Alzheimer's disease or other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect brain function and slow the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding oxidative stress and its role in Alzheimer's, suggesting that this approach could yield valuable insights.
Where this research is happening
Lubbock, United States
- Texas Tech University Health Scis Center — Lubbock, United States (Active)
Researchers
- Principal investigator: Lawrence, John Joshua — Texas Tech University Health Scis Center
- Study coordinator: Lawrence, John Joshua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.