Investigating how certain genes in immune cells contribute to fibrosis in scleroderma
Pathogenic Wnt-beta catenin target genes in macrophages and fibrosis
This study is looking at how certain immune cells change and contribute to the thickening of skin and organs in people with scleroderma, especially as they get older, to find new ways to help improve their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10651598 on NIH RePORTER |
What this research studies
This research focuses on systemic sclerosis (scleroderma), a disease that causes fibrosis in the skin and internal organs, particularly affecting lung function as patients age. The study examines how circulating monocytes transform into macrophages in damaged tissues and their role in fibrosis development. By using a mouse model and analyzing human lung macrophages from transplant patients, researchers aim to understand the signaling pathways involved, particularly the Wnt/β-catenin pathway, and how age affects fibrosis persistence. The goal is to identify potential therapeutic targets to improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with systemic sclerosis or scleroderma, particularly those experiencing lung fibrosis.
Not a fit: Patients with other forms of fibrosis not related to systemic sclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow or reverse fibrosis in patients with scleroderma.
How similar studies have performed: Previous research has shown promising results in understanding the role of macrophages in fibrosis, suggesting that this approach could yield significant insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Hinchcliff, Monique Evangeline — Yale University
- Study coordinator: Hinchcliff, Monique Evangeline
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.