Investigating how certain genes contribute to the growth of cancer stem cells in multiple myeloma
Core transcriptional regulators of malignant stem cell generation in multiple myeloma
This study is looking at how a protein called IRF4 affects the growth of cancer cells in multiple myeloma, with the hope of finding new ways to treat this blood cancer and improve outcomes for patients like you.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10926914 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of specific transcription factors, particularly IRF4, in the development of malignant stem-like cells in multiple myeloma, a type of blood cancer. By exploring how these factors influence cancer cell survival and regeneration in the bone marrow, the study aims to identify new therapeutic targets. The approach includes using novel RNA-targeted therapies to inhibit the expression of IRF4, which could potentially disrupt the growth of cancer cells. Patients may benefit from insights gained that could lead to more effective treatments for this aggressive cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with multiple myeloma, particularly those with high-risk features and poor prognosis.
Not a fit: Patients with early-stage multiple myeloma or those who do not have the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve survival rates for patients with multiple myeloma.
How similar studies have performed: Previous research has shown promise in targeting transcription factors in cancer, suggesting that this approach could yield significant advancements in treatment.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Crews, Leslie a — University of California, San Diego
- Study coordinator: Crews, Leslie a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.