Investigating how certain genes affect treatment resistance in childhood cancer
Chromatin regulators of stemness and therapy resistance in rhabdomyosarcoma
This study is looking at rhabdomyosarcoma, a type of cancer that affects kids and can be tough to treat, to find out why some tumors don't respond well to standard treatments, with the hope of discovering better ways to help kids fight this cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11231976 on NIH RePORTER |
What this research studies
This research focuses on rhabdomyosarcoma, a common type of soft-tissue cancer in children, which often resists standard treatments like chemotherapy and surgery. Researchers are using advanced techniques, including single-cell transcriptomics and animal models, to identify the molecular mechanisms that lead to treatment resistance and tumor recurrence. By profiling patient-derived samples, they aim to uncover different cell types within tumors that may contribute to poor outcomes. This understanding could lead to more effective therapies tailored to combat these resistant cancer cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with rhabdomyosarcoma who are undergoing or have undergone standard treatment.
Not a fit: Patients with other types of cancers or those who do not have rhabdomyosarcoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that reduce the risk of tumor recurrence and increase survival rates for children with rhabdomyosarcoma.
How similar studies have performed: Other research has shown promise in understanding cancer treatment resistance through similar molecular profiling techniques, indicating potential for success in this area.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Wei, Yun — Ut Southwestern Medical Center
- Study coordinator: Wei, Yun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.