Investigating how certain genes affect cardiovascular disease in women and transgender individuals.
Official title: Credentialing novel cardiovascular disease genes in women by sex-specific genomic investigation of insulin resistance
Funded at University of California, San Diego · NIH-10906093 · Data updated 2026-11-12
This study is looking at how genetics and hormones affect heart disease risk in women and transgender individuals, especially related to insulin resistance, to help create better ways to identify and treat those at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | August 25, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $513,937 |
| NIH project number | 5R01HL159760-04 |
| Project ID | NIH-10906093 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include women and transgender individuals who are at risk for cardiovascular disease, particularly those with insulin resistance.
✕Less likely to help
Patients who are not women or transgender individuals, or those without insulin resistance, may not benefit from this research.
What this research studies
This research focuses on understanding the genetic factors that contribute to cardiovascular disease (CVD) in women and transgender individuals, particularly in relation to insulin resistance. By conducting genetic association studies that consider sex differences, the research aims to uncover the molecular mechanisms behind CVD risk. The study will explore how sex hormones and chromosomal differences influence insulin resistance, which is a significant risk factor for CVD. The ultimate goal is to develop better screening methods and therapeutic options tailored specifically for women and transgender individuals at risk of CVD.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for cardiovascular disease in women and transgender individuals.
How similar studies have gone: Previous research has shown that sex-specific approaches in understanding cardiovascular disease can yield significant insights, suggesting that this study's focus on genetic factors is both relevant and potentially impactful.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Majithia, Amit — University of California, San Diego
- Study coordinator: Majithia, Amit
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.