Investigating how certain genes affect cancer cell growth and aging
Official title: Roles of TIMELESS in oncogene-induced senescence and oncogenic transformation
Funded at State University New York Stony Brook · NIH-10978277 · Data updated 2026-11-12
This study is looking at how a gene called TIMELESS affects the body's natural way of stopping early cancer cells from growing into more serious cancers, and it aims to find new ways to improve treatments for people with early-stage cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | August 16, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $358,702 |
| NIH project number | 1R01CA285515-01A1 |
| Project ID | NIH-10978277 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with early-stage cancers, particularly those with RAS mutations, who may benefit from targeted therapies aimed at enhancing oncogene-induced senescence.
✕Less likely to help
Patients with advanced-stage cancers or those without RAS mutations may not receive direct benefits from this research.
What this research studies
This research explores the role of a specific gene, TIMELESS, in the process of oncogene-induced senescence (OIS), which is a natural barrier that prevents early cancerous cells from becoming malignant. The study focuses on understanding how DNA damage and replication stress contribute to the failure of this barrier, potentially leading to cancer progression. By examining the mechanisms behind these processes, the research aims to identify new therapeutic strategies that could enhance the effectiveness of treatments for patients with early-stage cancers.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent the progression of early cancerous lesions into malignant tumors.
How similar studies have gone: Previous research has shown promising results in understanding oncogene-induced senescence and its implications for cancer treatment, indicating that this approach has potential for significant advancements.
Where this research is happening
-
State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Kim, Hyungjin — State University New York Stony Brook
- Study coordinator: Kim, Hyungjin
Related research
Other NIH-funded projects on the same topics.
-
Understanding how oral microbes interact at the single-cell level
Aimed at uncovering how bacteria in the mouth stick together and influence each other, using advanced imaging to reveal functional connections at the microscopic level.
-
Cellular and circuit-level mechanisms of HIV/NRTI-related pain in the context of opioids
This NIH grant explores how HIV medicines (NRTIs) and opioids may combine to cause chronic pain, aiming to help people living with HIV who experience pain.
-
Using a dye to see how kidneys work and how transporters act
A new, simple dye-based test could help doctors measure kidney tubular function and transporter activity more accurately in people with acute kidney problems.
-
Interneuronal aging in trauma-exposed World Trade Center responders
A study in WTC responders with PTSD will look at brain interneuron health using advanced imaging and proteins to understand how PTSD may affect aging brains.
-
Dynamic PTSD-Related Cognitive Risk in Aging WTC Responders
This project follows World Trade Center responders as they age to understand how PTSD symptoms relate to changes in thinking skills over time.
-
How CHIKV viruses adapt to mosquitoes and cause disease in people
This project explores how the chikungunya virus changes to become better at infecting mosquitoes and causing disease in humans, with the goal of understanding how to prevent transmission and illness.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.