Investigating how certain genes affect cancer cell growth and aging
Roles of TIMELESS in oncogene-induced senescence and oncogenic transformation
This study is looking at how a gene called TIMELESS affects the body's natural way of stopping early cancer cells from growing into more serious cancers, and it aims to find new ways to improve treatments for people with early-stage cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-10978277 on NIH RePORTER |
What this research studies
This research explores the role of a specific gene, TIMELESS, in the process of oncogene-induced senescence (OIS), which is a natural barrier that prevents early cancerous cells from becoming malignant. The study focuses on understanding how DNA damage and replication stress contribute to the failure of this barrier, potentially leading to cancer progression. By examining the mechanisms behind these processes, the research aims to identify new therapeutic strategies that could enhance the effectiveness of treatments for patients with early-stage cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with early-stage cancers, particularly those with RAS mutations, who may benefit from targeted therapies aimed at enhancing oncogene-induced senescence.
Not a fit: Patients with advanced-stage cancers or those without RAS mutations may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent the progression of early cancerous lesions into malignant tumors.
How similar studies have performed: Previous research has shown promising results in understanding oncogene-induced senescence and its implications for cancer treatment, indicating that this approach has potential for significant advancements.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Kim, Hyungjin — State University New York Stony Brook
- Study coordinator: Kim, Hyungjin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.