Investigating how certain genes affect blood vessel health in brain aneurysms
Official title: Endothelial Cell Reprogramming in Familial Intracranial Aneurysm
Funded at Yale University · NIH-11014420 · Data updated 2026-11-12
This study is looking at the genes that might make some families more likely to have bulges in their brain blood vessels, which can be dangerous, and it's for anyone who has a family history of these aneurysms to help find ways to prevent them from causing serious problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $589,159 |
| NIH project number | 5R01NS127469-03 |
| Project ID | NIH-11014420 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of intracranial aneurysms or those diagnosed with familial intracranial aneurysms.
✕Less likely to help
Patients without a family history of intracranial aneurysms or those with sporadic cases may not benefit from this research.
What this research studies
This research focuses on understanding the genetic factors that contribute to familial intracranial aneurysms, which are bulges in blood vessels in the brain that can lead to serious health issues if they rupture. The team is analyzing genetic data from families affected by these aneurysms to identify rare mutations that may increase risk. By using animal models and human endothelial cells, they aim to uncover how these mutations affect blood vessel formation and health. This could lead to new insights into preventing aneurysm ruptures and improving patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to better prevention strategies and treatments for patients at risk of intracranial aneurysms.
How similar studies have gone: Previous research has successfully identified genetic factors associated with other vascular conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Gunel, Murat — Yale University
- Study coordinator: Gunel, Murat
Related research
Other NIH-funded projects on the same topics.
-
Understanding how brain aneurysm walls and shape change over time
This project studies how small brain aneurysms grow and whether MRI features of the aneurysm wall and its shape can predict growth so doctors can better decide when treatment is needed.
-
Predicting brain aneurysm growth with advanced 4D MRI and tensor math
A research project uses 4D flow MRI and new math models to predict how brain aneurysms grow over time, helping doctors decide on safer treatments for people with UIAs.
-
How aging and aged (senescent) cells may cause brain aneurysm rupture
This research tests whether removing aging 'senescent' cells can lower the chance that a brain aneurysm will burst for people with intracranial aneurysms.
-
Reprogramming blood-vessel lining cells in inherited brain aneurysms
This project aims to find out whether fixing gene-related changes in the cells that line brain arteries can lower aneurysm risk in people with a family history.
-
How tiny cell structures (podosomes) may weaken brain arteries and cause aneurysms
Testing whether podosomes — small structures inside blood vessel cells — make brain arteries weaker and raise the risk of aneurysm rupture for people with or at risk of brain aneurysms.
-
How cells' cleanup of vessel attachments may affect brain aneurysms
This project looks at whether a cellular cleanup process in blood‑vessel lining cells weakens brain arteries and contributes to aneurysms in people at risk for intracranial aneurysm.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.