Investigating how certain genes affect blood vessel health in brain aneurysms
Endothelial Cell Reprogramming in Familial Intracranial Aneurysm
This study is looking at the genes that might make some families more likely to have bulges in their brain blood vessels, which can be dangerous, and it's for anyone who has a family history of these aneurysms to help find ways to prevent them from causing serious problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11014420 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic factors that contribute to familial intracranial aneurysms, which are bulges in blood vessels in the brain that can lead to serious health issues if they rupture. The team is analyzing genetic data from families affected by these aneurysms to identify rare mutations that may increase risk. By using animal models and human endothelial cells, they aim to uncover how these mutations affect blood vessel formation and health. This could lead to new insights into preventing aneurysm ruptures and improving patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of intracranial aneurysms or those diagnosed with familial intracranial aneurysms.
Not a fit: Patients without a family history of intracranial aneurysms or those with sporadic cases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention strategies and treatments for patients at risk of intracranial aneurysms.
How similar studies have performed: Previous research has successfully identified genetic factors associated with other vascular conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Gunel, Murat — Yale University
- Study coordinator: Gunel, Murat
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.