Investigating how certain gene changes contribute to leukemia development
Official title: The role for phase separation in oncogenesis and aberrant chromatin looping formation
Funded at Duke University · NIH-10866550 · Data updated 2026-11-12
This study is looking at how changes in a specific gene called NUP98 might contribute to the development of acute myeloid leukemia (AML), with the hope of finding new ways to understand and treat the disease for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | September 4, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $548,895 |
| NIH project number | 5R01CA271603-04 |
| Project ID | NIH-10866550 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with acute myeloid leukemia, particularly those with NUP98 gene rearrangements.
✕Less likely to help
Patients with other types of leukemia or those without NUP98 gene rearrangements may not benefit from this research.
What this research studies
This research focuses on understanding the role of specific gene rearrangements, particularly the NUP98 gene, in the development of acute myeloid leukemia (AML). By examining how these genetic changes lead to abnormal chromatin behavior and gene expression, the study aims to uncover mechanisms that drive leukemia progression. The researchers will utilize advanced techniques to analyze the interactions between proteins and DNA, particularly looking at how certain regions of proteins can influence the formation of liquid-like structures in cells, which may play a critical role in cancer development. Patients may benefit from insights gained into how these genetic factors contribute to their disease and potential new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating acute myeloid leukemia.
How similar studies have gone: Previous research has shown promising results in understanding the role of gene rearrangements in leukemia, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Wang, G Greg — Duke University
- Study coordinator: Wang, G Greg
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.