Investigating how certain fibroblasts contribute to cancer in patients with ulcerative colitis
The miR-20/c-Myc/E2F Regulatory Axis is Critical for the Tumor Promoting Activity of Inflammatory Fibroblasts in Colitis-Associated Cancer
This study is looking at how certain cells in the body, called inflammatory fibroblasts, might contribute to a higher risk of cancer in people with ulcerative colitis, and it hopes to find new ways to help reduce that risk for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10571865 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of inflammatory fibroblasts in the development of cancer associated with ulcerative colitis. It aims to identify the molecular mechanisms that lead to increased tumor risk in these patients, particularly looking at the interactions between specific genes and inflammatory signals. By studying the behavior of fibroblasts in the context of chronic inflammation, the research seeks to uncover potential targets for preventive therapies. Patients with ulcerative colitis may find this research relevant as it could lead to new strategies for reducing their cancer risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with ulcerative colitis who are at an increased risk for developing colitis-associated cancer.
Not a fit: Patients without a diagnosis of ulcerative colitis or those who do not have a history of chronic inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new preventive treatments for patients with ulcerative colitis to reduce their risk of developing colon cancer.
How similar studies have performed: While the specific regulatory axis being studied is novel, previous research has shown that targeting inflammatory pathways can be effective in cancer prevention.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Huang, Emina Hui-Na — Ut Southwestern Medical Center
- Study coordinator: Huang, Emina Hui-Na
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.