Investigating how certain fatty acids can help prevent obesity
n-3 PUFA derived epoxides and thermogenesis for obesity prevention
This study is looking at how certain healthy fats can help your body burn more energy and prevent weight gain, and it could lead to new ways for adults to manage their weight without the usual side effects of other methods.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Knoxville NIH-funded |
| Lab location | 1 site (Knoxville, United States) |
| Project ID | NIH-10438276 on NIH RePORTER |
What this research studies
This research explores the role of n-3 polyunsaturated fatty acids, specifically epoxyeicosatetraenoic acid, in stimulating thermogenesis to prevent obesity. The study aims to understand how these fatty acids can enhance energy expenditure and improve metabolism by targeting brown adipose tissue in adults. By using a pharmacological inhibitor to stabilize these fatty acids, the research seeks to find a practical method for promoting weight management without the side effects associated with traditional approaches. Patients may benefit from insights into new dietary or therapeutic strategies for obesity prevention.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are at risk of obesity or related metabolic disorders.
Not a fit: Patients who are not overweight or do not have metabolic disorders may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new methods for preventing obesity and its related health issues.
How similar studies have performed: Other research has shown promising results in using fatty acids for metabolic health, but this specific approach is relatively novel.
Where this research is happening
Knoxville, United States
- University of Tennessee Knoxville — Knoxville, United States (Active)
Researchers
- Principal investigator: Zhao, Ling — University of Tennessee Knoxville
- Study coordinator: Zhao, Ling
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.