Investigating how certain enzymes contribute to antibiotic resistance
Radical SAM-dependent methylation in antibiotic resistance
This study is looking at how a certain enzyme helps bacteria resist antibiotics, which makes infections tougher to treat, and by understanding this enzyme better, we hope to find new ways to help patients get better from these stubborn infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11074128 on NIH RePORTER |
What this research studies
This research focuses on understanding how a specific enzyme, Cfr, modifies the bacterial ribosome, leading to antibiotic resistance. By methylating a key nucleotide in the ribosome, Cfr allows bacteria to survive treatments with various antibiotics, making infections harder to treat. The study aims to characterize different variants of the Cfr enzyme and their mechanisms, which could help in developing new strategies to combat antibiotic-resistant infections. Patients may benefit from insights gained that could lead to more effective treatments against resistant bacterial infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from infections caused by antibiotic-resistant bacteria.
Not a fit: Patients with infections that are not caused by antibiotic-resistant bacteria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively combat antibiotic-resistant bacterial infections.
How similar studies have performed: Other research has shown success in characterizing antibiotic resistance mechanisms, indicating that this approach has potential for meaningful advancements.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Fujimori, Danica Galonic — University of California, San Francisco
- Study coordinator: Fujimori, Danica Galonic
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.