Investigating how certain enzymes can help reduce physical decline in aging individuals
Targeting muscle kynurenine aminotransferases and the AHR pathway to mitigate age-related physical decline
This study is looking at how certain enzymes might affect muscle strength and overall health as we age, especially in older adults, to find ways to help them stay strong and active.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10902589 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of specific enzymes in the aging process, particularly how they relate to muscle weakness and frailty in older adults. By examining the relationship between elevated levels of L-kynurenine and age-related physical decline, the study aims to identify potential interventions that could reverse these effects. The approach involves analyzing the function of kynurenine aminotransferases and their impact on muscle health, with the goal of developing strategies to improve physical function in the elderly.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing muscle weakness or frailty.
Not a fit: Patients who are not elderly or do not exhibit signs of muscle weakness or frailty may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance physical function and quality of life for older adults.
How similar studies have performed: While there is emerging evidence linking kynurenine levels to frailty, this specific approach to targeting muscle enzymes in aging is relatively novel and has not been extensively tested.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Wimberly, Keon — University of Florida
- Study coordinator: Wimberly, Keon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.