Investigating how certain enzymes affect the evolution of precancerous cells
Official title: Exploring the Impact of Base Deaminase Deregulation on Precancer Evolution
Funded at University of California, San Diego · NIH-11028876 · Data updated 2026-11-12
This study is looking at how two specific enzymes might affect the growth of acute myeloid leukemia (AML) by causing changes in cancer cells, and it hopes to find new ways to treat this type of blood cancer using samples from patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $444,952 |
| NIH project number | 1R01CA296974-01 |
| Project ID | NIH-11028876 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients diagnosed with acute myeloid leukemia or related myeloproliferative neoplasms.
✕Less likely to help
Patients with other types of cancers or those not diagnosed with myeloproliferative neoplasms may not benefit from this research.
What this research studies
This research focuses on understanding the roles of specific enzymes, APOBEC3C and ADAR1, in the progression of certain blood cancers, particularly acute myeloid leukemia (AML). By studying how these enzymes contribute to genetic changes in cancer cells, the research aims to uncover mechanisms that lead to cancer stem cell generation and resistance to treatments. Patients' primary samples will be analyzed to determine the functional relevance of enzyme deregulation in cancer progression. This could provide insights into new therapeutic strategies for managing AML.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and better outcomes for patients with acute myeloid leukemia.
How similar studies have gone: Previous research has shown promising results in understanding the role of enzyme deregulation in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Jamieson, Catriona Helen Macleod — University of California, San Diego
- Study coordinator: Jamieson, Catriona Helen Macleod
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.