Investigating how certain enzymes affect metabolism and aging
Flavin-containing monooxygenases in endogenous metabolism and aging
This study is looking at how certain enzymes in our bodies can help us stay healthy and live longer, especially when we eat less, and it hopes to find ways to boost these benefits without making big changes to our diets, which could be helpful for people as they age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10989923 on NIH RePORTER |
What this research studies
This research explores the role of flavin-containing monooxygenases (FMOs) in metabolism and aging. It aims to understand how these enzymes, which are activated by dietary restriction, can improve health and longevity. By studying the effects of FMOs in model organisms like C. elegans, the research seeks to uncover mechanisms that could mimic the benefits of dietary restriction without requiring significant changes to human diets. Patients may benefit from insights into how to enhance their health as they age.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults interested in understanding how metabolic processes affect their health as they age.
Not a fit: Patients with acute health conditions unrelated to aging or metabolism may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving health and longevity in aging populations.
How similar studies have performed: Previous research has shown promising results regarding the role of FMOs in longevity and health, indicating that this approach has potential for success.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Leiser, Scott F — University of Michigan at Ann Arbor
- Study coordinator: Leiser, Scott F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.