Investigating how certain enzymes affect cell behavior in health and disease
Structure and Regulation of Ectodomain Sheddases in Development and Disease
This study is looking at how certain enzymes help cells change their surface proteins, which affects how they stick together and communicate, and it aims to find out how these processes work in both healthy and diseased states, so that patients can gain a better understanding of their health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11090516 on NIH RePORTER |
What this research studies
This research focuses on ectodomain shedding, a crucial biological process that allows cells to modify their membrane proteins, influencing how they adhere to each other and communicate. The study aims to understand the mechanisms behind specific enzymes, particularly the ADAM family, which play significant roles in various biological functions, including immune response and heart valve development. By examining the activation and regulation of these enzymes, the research seeks to uncover their roles in both normal development and disease conditions. Patients may benefit from insights gained into how these enzymes contribute to health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to immune function or heart valve abnormalities.
Not a fit: Patients with unrelated conditions or those not affected by enzyme dysregulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases linked to enzyme dysregulation.
How similar studies have performed: Previous research has shown promising results in understanding similar enzyme functions, indicating potential for significant advancements in this area.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Seegar, Tom C M — University of Cincinnati
- Study coordinator: Seegar, Tom C M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.