Investigating how certain enzymes affect blood pressure regulation.
The roles of PLD and DGK isoforms in PIP2 homeostasis during PLC signaling
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-10898647
This study is looking at how certain enzymes help control a fat in the body that affects blood pressure, with the goal of finding new treatment options for people who struggle with high blood pressure that doesn't respond to regular medications.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-10898647 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of specific enzymes in regulating a lipid called phosphatidylinositol 4,5-bisphosphate (PIP2), which is crucial for controlling blood pressure. It aims to identify how different isoforms of diacylglycerol kinases (DGK) and phospholipase D (PLD) contribute to maintaining PIP2 levels during phospholipase C (PLC) signaling. By exploring these mechanisms, the research seeks to find new targets for drug development that could help patients with resistant hypertension, who do not respond to standard treatments. The study employs advanced techniques, including CRISPR, to manipulate these enzymes and observe their effects on blood pressure regulation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with resistant hypertension who have not achieved adequate blood pressure control with multiple antihypertensive medications.
Not a fit: Patients with hypertension that responds well to standard antihypertensive treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients with resistant hypertension, improving their blood pressure control.
How similar studies have performed: While the specific approach of targeting DGK and PLD isoforms is novel, similar research has shown promise in identifying alternative pathways for managing hypertension.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WECKERLY, CLAIRE — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: WECKERLY, CLAIRE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.