Investigating how certain environmental exposures trigger autoimmune responses
Early Pathogenic Steps in Xenobiotic-Induced Autoimmunity
This study is looking at how things in our environment, like mercury, might trigger the immune system to start attacking the body, which can lead to autoimmune diseases, and it's designed for anyone interested in understanding how these conditions begin and how we might prevent them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10991430 on NIH RePORTER |
What this research studies
This research focuses on understanding the early steps that lead to autoimmune diseases, particularly how environmental factors, like mercury exposure, can initiate the production of autoantibodies. By using animal models that replicate these conditions, the study aims to identify the specific molecular and cellular changes that occur when the immune system begins to malfunction. This approach allows researchers to pinpoint the exact moments when B cell tolerance is lost, leading to autoimmune responses. The findings could provide insights into the mechanisms behind autoimmune diseases and potential preventive strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of autoimmune diseases or those who have been exposed to environmental toxins like mercury.
Not a fit: Patients with established autoimmune diseases unrelated to environmental triggers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention of autoimmune diseases triggered by environmental factors.
How similar studies have performed: Previous research has shown success in using animal models to study the mechanisms of autoimmunity, indicating that this approach is promising.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Pollard, Kenneth Michael — Scripps Research Institute, the
- Study coordinator: Pollard, Kenneth Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.