Investigating how certain E. coli bacteria may influence the development of pre-cancer in the colon
Colibactin-Producing Escherichia coli as an Environmental Stimulus Shaping Pre-Cancer Progression
This study is looking at how certain bacteria in the gut might influence the development of colon pre-cancers and help us find ways to predict which ones could turn into cancer, so if you're a patient who has had polyps removed, your participation could really help us learn more about this important issue.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10926864 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of colibactin-producing Escherichia coli in the progression of pre-cancerous conditions in the colon. By examining the relationship between these bacteria and the development of colorectal cancer, the study aims to identify molecular markers that could help predict which pre-cancers are likely to progress. The approach involves analyzing the microbiota composition in patients and how it may contribute to cancer risk, particularly after polypectomy procedures. Patients may be involved in providing biological samples for analysis to better understand these mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of colon polyps or pre-cancerous lesions.
Not a fit: Patients without any history of colon polyps or those who have not undergone colonoscopy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for identifying individuals at higher risk of developing colorectal cancer, allowing for earlier interventions.
How similar studies have performed: Other research has shown promising results in understanding the microbiota's role in cancer development, suggesting that this approach may yield valuable insights.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Shrubsole, Martha J. — Vanderbilt University Medical Center
- Study coordinator: Shrubsole, Martha J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.