Investigating how certain DNA damage affects cancer risk and repair mechanisms
NIH resubmission Deyu Li - Etheno adductome and repair pathways
This study is looking at how long-term inflammation and infections might increase the risk of cancer by damaging DNA, and it aims to understand how our bodies repair this damage, which is important for keeping our genes healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rhode Island NIH-funded |
| Lab location | 1 site (Kingston, United States) |
| Project ID | NIH-11032870 on NIH RePORTER |
What this research studies
This research explores the relationship between chronic inflammation, persistent infections, and the risk of developing cancer. It focuses on how reactive species from lipid peroxidation can damage DNA, forming specific etheno-type adducts that may lead to genomic instability and mutations. The study aims to understand the repair mechanisms of these DNA damages, particularly through base excision repair and direct reversal repair pathways, which are crucial for maintaining genomic integrity. By examining these processes, the research seeks to fill gaps in knowledge regarding the mutagenicity of newly identified etheno adducts.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with chronic inflammatory conditions or persistent infections that may increase their cancer risk.
Not a fit: Patients who do not have chronic inflammation or related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of cancer risk factors and potential new strategies for cancer prevention and treatment.
How similar studies have performed: Other research has shown success in understanding DNA damage and repair mechanisms, but the specific focus on newly identified etheno adducts is relatively novel.
Where this research is happening
Kingston, United States
- University of Rhode Island — Kingston, United States (Active)
Researchers
- Principal investigator: Li, Deyu — University of Rhode Island
- Study coordinator: Li, Deyu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.