Investigating how certain dietary compounds can improve wound healing in diabetic patients
Diversity Supplement to “Mechanistic study of Small-molecular Therapy in diabetic Wound Healing”
['FUNDING_R01'] · WAYNE STATE UNIVERSITY · NIH-10837420
This study is looking at how two natural compounds, Trans-resveratrol and hesperetin, might help improve healing for people with diabetes who have foot ulcers, by understanding how they support the growth of new blood vessels needed for healing.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WAYNE STATE UNIVERSITY (nih funded) |
| Locations | 1 site (DETROIT, UNITED STATES) |
| Trial ID | NIH-10837420 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how two dietary compounds, Trans-resveratrol and hesperetin, can enhance wound healing in patients with diabetes, particularly those suffering from diabetic foot ulcers. The study aims to explore the molecular mechanisms behind these compounds' effects on endothelial cells, which are crucial for forming new blood vessels during the healing process. By examining how these compounds influence gene expression and promote the production of pro-angiogenic factors, the research seeks to identify new strategies for improving wound care protocols. Patients may benefit from insights that could lead to more effective treatments for diabetic wounds.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diabetes who are experiencing foot ulcers or are at risk of developing them.
Not a fit: Patients without diabetes or those who do not have any issues related to wound healing may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved healing of diabetic foot ulcers, potentially reducing amputation rates among diabetic patients.
How similar studies have performed: Previous research has shown promising results with similar dietary compounds in enhancing wound healing, indicating potential for success in this approach.
Where this research is happening
DETROIT, UNITED STATES
- WAYNE STATE UNIVERSITY — DETROIT, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YI, ZHENGPING — WAYNE STATE UNIVERSITY
- Study coordinator: YI, ZHENGPING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.