Investigating how certain dietary chemicals may harm dopamine-producing neurons
Official title: Mechanisms of PhIP-induced dopaminergic neurotoxicity
Funded at Purdue University · NIH-10595271 · Data updated 2026-11-12
This study is looking at how certain harmful substances in our food might affect brain cells that help control movement, which is important for people with Parkinson's disease, to better understand how diet can impact brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project start | September 15, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $1,563,395 |
| NIH project number | 2R01ES025750-06A1 |
| Project ID | NIH-10595271 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for Parkinson's disease or those concerned about the impact of diet on neurological health.
✕Less likely to help
Patients who do not consume foods containing heterocyclic aromatic amines or those with established Parkinson's disease may not benefit from this research.
What this research studies
This research explores the effects of dietary toxicants known as heterocyclic aromatic amines (HAAs) on dopamine-producing neurons, which are crucial for motor function. The study utilizes various models, including cellular and rodent systems, to understand the mechanisms behind neurotoxicity, such as oxidative damage and mitochondrial dysfunction. By identifying how these toxicants contribute to neurodegeneration, particularly in the context of Parkinson's disease, the research aims to fill significant gaps in our understanding of dietary influences on neurological health.
Why it matters
Potential benefit: If successful, this research could lead to better dietary recommendations and interventions to prevent or mitigate neurodegenerative diseases like Parkinson's.
How similar studies have gone: Previous research has shown promising results in understanding the neurotoxic effects of dietary components, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Purdue University
West Lafayette, United States Active
Researchers
- Principal investigator: Cannon, Jason R — Purdue University
- Study coordinator: Cannon, Jason R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.