Investigating how certain compounds affect liver cancer development in patients with diabetes and liver disease.
Official title: Matrix in pre-cirrhotic HCC
Funded at Stanford University · NIH-11042235 · Data updated 2026-11-12
This study is looking at how a substance called advanced glycation end products (AGEs) might cause liver problems and cancer in people with type 2 diabetes, even before serious liver damage happens, to help find new ways to prevent or treat liver cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | March 15, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $571,139 |
| NIH project number | 5R01CA277710-03 |
| Project ID | NIH-11042235 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with non-alcoholic steatohepatitis and type 2 diabetes mellitus.
✕Less likely to help
Patients without diabetes or liver disease may not receive any benefit from this research.
What this research studies
This research focuses on understanding how non-alcoholic steatohepatitis (NASH), particularly in patients with type 2 diabetes mellitus (T2DM), can lead to liver cancer (HCC) even before cirrhosis develops. The study examines the role of advanced glycation end products (AGEs) in promoting liver injury and cancer progression. By using animal models and dietary modifications, researchers aim to uncover the mechanisms by which AGEs contribute to changes in liver tissue that may facilitate cancer development. Patients may benefit from insights that could lead to new prevention strategies or treatments for liver cancer associated with diabetes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing liver cancer in patients with diabetes and liver disease.
How similar studies have gone: Previous research has shown that targeting advanced glycation end products can improve liver conditions, suggesting potential for success in this area.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Torok, Natalie J. — Stanford University
- Study coordinator: Torok, Natalie J.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.