Investigating how certain compounds affect bone fractures in people with type 2 diabetes
Official title: Effects of Advanced Glycation Endproducts on Type 2 Diabetic and Fragility Fractures
Funded at Rensselaer Polytechnic Institute · NIH-11077226 · Data updated 2026-11-12
This study is looking at how certain substances in the body, called AGEs, might increase the risk of fragile bones in people with type 2 diabetes, even if their bone density seems fine, to help find better ways to predict fractures in diabetic patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rensselaer Polytechnic Institute NIH-funded |
| Lab location | 1 site (Troy, United States) |
| Project start | August 1, 2022 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $550,998 |
| NIH project number | 5R01AG075654-04 |
| Project ID | NIH-11077226 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with type 2 diabetes who are at risk for bone fractures.
✕Less likely to help
Patients without type 2 diabetes or those who do not have concerns about bone health may not benefit from this research.
What this research studies
This research explores the relationship between advanced glycation endproducts (AGEs) and the risk of fragility fractures in individuals with type 2 diabetes. The study aims to identify specific markers, such as carboxymethyl-lysine (CML), that may indicate increased fracture risk despite high bone mineral density. By analyzing bone samples and employing advanced measurement techniques, the research seeks to uncover how these compounds affect bone quality and toughness. This could lead to improved methods for predicting fracture risk in diabetic patients.
Why it matters
Potential benefit: If successful, this research could lead to better prediction and prevention of fragility fractures in patients with type 2 diabetes.
How similar studies have gone: Previous research has indicated that understanding the role of AGEs in bone health could lead to significant advancements in fracture risk assessment, suggesting a promising avenue for this investigation.
Where this research is happening
-
Rensselaer Polytechnic Institute
Troy, United States Active
Researchers
- Principal investigator: Vashishth, Deepak — Rensselaer Polytechnic Institute
- Study coordinator: Vashishth, Deepak
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.