Investigating how certain compounds affect blood cell development
Official title: Roles of DPA derived specialized pre-resolving mediators during vertebrate hematopoiesis
Funded at University of Mississippi Med Ctr · NIH-10996096 · Data updated 2026-11-12
This study is looking at how certain natural compounds can help boost the production of blood cells, using zebrafish embryos to find new ways to treat blood disorders like anemia and blood cancers, which could lead to better treatment options for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Mississippi Med Ctr NIH-funded |
| Lab location | 1 site (Jackson, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $32,974 |
| NIH project number | 5F31HL170707-02 |
| Project ID | NIH-10996096 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults suffering from blood disorders, including anemia and blood cancers.
✕Less likely to help
Patients with non-blood-related conditions or those who are not adults may not receive benefits from this research.
What this research studies
This research focuses on understanding the role of specialized pro-resolving mediators derived from docosapentaenoic acid in the development of blood cells. By using zebrafish embryos as a model, the researchers will screen various compounds to identify those that can enhance the production of hematopoietic stem cells and red blood cells. The study aims to evaluate the therapeutic potential of these compounds for treating blood disorders such as anemia and blood cancers. Patients may benefit from new treatment options that target the underlying mechanisms of these diseases.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that improve blood cell production and treat blood-related diseases more effectively.
How similar studies have gone: While the approach of using specialized mediators in blood cell development is promising, it is relatively novel and has not been extensively tested in human subjects.
Where this research is happening
-
University of Mississippi Med Ctr
Jackson, United States Active
Researchers
- Principal investigator: Nguyen, Kim Uyen — University of Mississippi Med Ctr
- Study coordinator: Nguyen, Kim Uyen
Related research
Other NIH-funded projects on the same topics.
-
Understanding how HTLV-1 hides inside immune cells to drive ATLL
A research project at the University of Mississippi Medical Center is studying how HTLV-1 makes monocytes and macrophages harbor the virus, with the goal of finding ways to restore the body’s own ability to clear it and slow ATL/ATLL progression.
-
Placental support cells and fetal red blood cell quality in preeclampsia
This grant studies how placental support cells in preeclampsia affect the development and quality of a baby’s red blood cells.
-
Epigenetic clues to preeclampsia in pregnancy
This grant explores how epigenetic changes and paternal factors may contribute to preeclampsia, a condition that can affect pregnancy health.
-
Fentanyl use during pregnancy and its effects on mom, placenta, and baby
This project studies how fentanyl use during pregnancy affects a mother's health, the placenta, and the development of the child.
-
Professional Development Core for Clinical & Translational Research in Mississippi
A grant to strengthen clinical and translational research training and community-engaged programs in Mississippi to accelerate care for chronic diseases including diabetes and dementia.
-
RS Core: Support for Clinical Research Development and Population Health in Mississippi
A patient-facing program to help doctors and researchers design and run clinical, translational, and community health studies more effectively.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.