Investigating how certain complexes can help reactivate latent HIV
POLYCOMB REPRESSIVE COMLEXE AS KEY REGULATORS OF HIV LATENCY AND TARGETS FOR LATENCY REVERSAL
This study is looking at how certain proteins in the body can help keep the HIV virus hidden and aims to find ways to wake up the virus so it can be cleared out, which could lead to new treatments for people living with HIV.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10656584 on NIH RePORTER |
What this research studies
This research focuses on understanding how Polycomb Repressive Complexes regulate HIV latency, which is the state where the virus remains dormant in the body despite treatment. By manipulating these complexes, the goal is to reactivate the latent virus, allowing for its potential elimination. The approach involves using chemical strategies to disrupt the epigenetic processes that keep the virus hidden, thereby promoting viral expression and clearance. This could lead to new treatments aimed at curing HIV in chronically infected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are chronically infected with HIV and have a history of viral latency.
Not a fit: Patients who are newly diagnosed with HIV or those who do not have a history of viral latency may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that effectively eliminate latent HIV from the body, potentially curing patients.
How similar studies have performed: Previous studies have shown promising results in reactivating HIV transcription through similar epigenetic manipulation strategies, indicating potential for success in this approach.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: James, Lindsey Ingerman — Univ of North Carolina Chapel Hill
- Study coordinator: James, Lindsey Ingerman
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.