Investigating how certain channels in the brain affect opioid tolerance and withdrawal.
KATP Channels as Downstream targets of adenylyl cyclases during opioid tolerance and withdrawal
This study is looking at how using opioids for a long time can change the way our nerves work, which might make us feel more pain, and it's aimed at helping people who are dealing with opioid tolerance and withdrawal.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project ID | NIH-11187166 on NIH RePORTER |
What this research studies
This research aims to explore the cellular mechanisms behind opioid tolerance and withdrawal by focusing on the role of adenylyl cyclase signaling and potassium channels in the nervous system. Using rodent models, the study will examine how chronic opioid exposure alters the activity of these channels, potentially leading to increased pain sensitivity. By identifying key intracellular targets, the research seeks to uncover new insights into how opioids affect neuronal excitability and pain perception, which could inform future treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing opioid tolerance or withdrawal symptoms.
Not a fit: Patients who are not currently using opioids or those without a history of opioid tolerance or withdrawal may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing opioid tolerance and withdrawal symptoms, ultimately enhancing patient care.
How similar studies have performed: Previous research has shown promising results in understanding the role of adenylyl cyclase in opioid signaling, suggesting that this approach may yield valuable insights.
Where this research is happening
Amherst, United States
- State University of New York at Buffalo — Amherst, United States (Active)
Researchers
- Principal investigator: Klein, Amanda Helen — State University of New York at Buffalo
- Study coordinator: Klein, Amanda Helen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.