Investigating how certain channels in our cells work and their role in diseases like cancer
Structure and function of Transient Receptor Potential Channels
['FUNDING_R01'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-11045698
This study is looking at special proteins in our cells that help us feel things like temperature and pain, to see how changes in our genes might affect their role in diseases like cancer, with the hope of finding new ways to create better treatments for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11045698 on ClinicalTrials.gov |
What this research studies
This research focuses on Transient Receptor Potential (TRP) channels, which are important cellular sensors that help our bodies respond to various stimuli such as temperature and pain. The study aims to understand the structure and function of these channels, particularly how genetic variations can affect their role in diseases, including cancer. By using advanced biophysical and biochemical methods, the researchers will explore how these channels can be targeted for new therapeutic strategies. This work could lead to better drug designs that specifically target these channels to improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic variations affecting TRP channels or those diagnosed with cancers related to these channels.
Not a fit: Patients without any genetic variations in TRP channels or those not affected by related diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cancer and other diseases by targeting TRP channels.
How similar studies have performed: Previous research has shown promise in targeting TRP channels for therapeutic purposes, indicating potential success for this approach.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SOBOLEVSKY, ALEXANDER — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: SOBOLEVSKY, ALEXANDER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer therapy