Investigating how certain channels in our cells work and their role in diseases like cancer
Official title: Structure and function of Transient Receptor Potential Channels
Funded at Columbia University Health Sciences · NIH-11045698 · Data updated 2026-11-12
This study is looking at special proteins in our cells that help us feel things like temperature and pain, to see how changes in our genes might affect their role in diseases like cancer, with the hope of finding new ways to create better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $414,452 |
| NIH project number | 5R01CA206573-08 |
| Project ID | NIH-11045698 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic variations affecting TRP channels or those diagnosed with cancers related to these channels.
✕Less likely to help
Patients without any genetic variations in TRP channels or those not affected by related diseases may not benefit from this research.
What this research studies
This research focuses on Transient Receptor Potential (TRP) channels, which are important cellular sensors that help our bodies respond to various stimuli such as temperature and pain. The study aims to understand the structure and function of these channels, particularly how genetic variations can affect their role in diseases, including cancer. By using advanced biophysical and biochemical methods, the researchers will explore how these channels can be targeted for new therapeutic strategies. This work could lead to better drug designs that specifically target these channels to improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cancer and other diseases by targeting TRP channels.
How similar studies have gone: Previous research has shown promise in targeting TRP channels for therapeutic purposes, indicating potential success for this approach.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Sobolevsky, Alexander — Columbia University Health Sciences
- Study coordinator: Sobolevsky, Alexander
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.