Investigating how certain cells in the lungs behave in pulmonary hypertension
Official title: Pulmonary Artery Endothelial Cell Endotypes and the Role of Anoikis Resistance in Pulmonary Hypertension
Funded at Rhode Island Hospital · NIH-11047124 · Data updated 2026-11-12
This study is looking at how certain cells in the lungs behave in people with pulmonary arterial hypertension (PAH) to find out why they don’t die off as expected, which could help us discover new ways to treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rhode Island Hospital NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | March 1, 2025 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $692,768 |
| NIH project number | 1R01HL174007-01A1 |
| Project ID | NIH-11047124 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pulmonary arterial hypertension, particularly those undergoing right heart catheterization.
✕Less likely to help
Patients with mild pulmonary hypertension or those without a confirmed diagnosis of pulmonary arterial hypertension may not benefit from this research.
What this research studies
This research focuses on pulmonary arterial hypertension (PAH), a serious condition characterized by dysfunction in the cells lining the blood vessels of the lungs. The team will collect endothelial cells from patients undergoing right heart catheterization, a common diagnostic procedure for PAH, and analyze these cells to understand their behavior and characteristics. By examining how these cells resist programmed cell death when detached from the vessel wall, the researchers aim to uncover new insights into the disease's progression and potential treatment targets.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve outcomes for patients with pulmonary hypertension.
How similar studies have gone: Previous research has shown promising results in understanding endothelial cell behavior in other vascular diseases, suggesting that this approach may yield valuable insights in PAH as well.
Where this research is happening
-
Rhode Island Hospital
Providence, United States Active
Researchers
- Principal investigator: Ventetuolo, Corey E — Rhode Island Hospital
- Study coordinator: Ventetuolo, Corey E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.