Investigating how certain cells develop into different types of tissues in the nervous system.
Cell lineage and transcriptional analysis of the vertebrate neural plate border
This study is looking at how certain cells in the body, which help form the face and sensory organs, develop and what keeps them flexible enough to become different types of cells, with the hope that it will help us understand and improve treatments for birth defects related to these areas.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project ID | NIH-11005701 on NIH RePORTER |
What this research studies
This research focuses on understanding the development of neural crest and ectodermal placode cells, which originate from the neural plate border. It examines how these cells can express characteristics of multiple lineages, potentially influencing the formation of craniofacial structures and sensory organs. By analyzing gene expression and the role of specific transcription factors, the research aims to uncover the mechanisms that maintain the multipotency of these cells. Patients may benefit from insights gained into congenital abnormalities related to craniofacial and sensory system development.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with congenital craniofacial abnormalities or related developmental disorders.
Not a fit: Patients with conditions unrelated to craniofacial or sensory system development may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for congenital defects affecting craniofacial and sensory structures.
How similar studies have performed: Other research has shown promising results in understanding cell lineage and development in similar contexts, suggesting that this approach could yield valuable insights.
Where this research is happening
Pasadena, United States
- California Institute of Technology — Pasadena, United States (Active)
Researchers
- Principal investigator: Bronner, Marianne — California Institute of Technology
- Study coordinator: Bronner, Marianne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.