Investigating how certain cells contribute to shoulder injuries from rotator cuff tears.
Official title: The role(s) of muscle resident fibro-adipogenic progenitor cells in massive rotator cuff tear pathologies.
Funded at Duke University · NIH-11055273 · Data updated 2026-11-12
This study is looking at how certain cells in the body might affect the healing process after a rotator cuff tear in the shoulder, which could help us find better ways to treat people with this common injury.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $41,893 |
| NIH project number | 5F31AR082701-02 |
| Project ID | NIH-11055273 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced rotator cuff tears and are seeking treatment options.
✕Less likely to help
Patients with shoulder injuries not related to rotator cuff tears may not benefit from this research.
What this research studies
This research focuses on understanding the role of specific cells called fibro-adipogenic progenitor cells in the development of rotator cuff tears, which are common shoulder injuries. The study will use mouse models to explore how these cells contribute to muscle fat accumulation and fibrosis after a rotator cuff tear occurs. By analyzing the molecular signals and factors secreted by these cells, the research aims to uncover the mechanisms behind muscle atrophy associated with these injuries. This could lead to better treatment strategies for patients suffering from rotator cuff tears.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies that reduce muscle atrophy and enhance recovery for patients with rotator cuff tears.
How similar studies have gone: Previous studies have shown promising results in understanding the role of similar cell types in muscle injuries, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Rueckert, Helen — Duke University
- Study coordinator: Rueckert, Helen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.