Investigating how certain cells contribute to pancreatic cancer development
The role of mesothelial-derived cancer-associated fibroblasts in the pathogenesis of pancreatic ductal adenocarcinoma
This study is looking at how certain cells from the lining of the pancreas might help pancreatic cancer grow and spread, with the hope of finding new ways to treat this tough disease.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10900899 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of mesothelial-derived cancer-associated fibroblasts in pancreatic ductal adenocarcinoma (PDA), a highly lethal form of cancer. The study examines how these fibroblasts interact with immune and cancer cells, potentially influencing disease progression. Using mouse models, researchers will explore the origins and functions of these fibroblasts, particularly their ability to produce cytokines that may affect tumor behavior. The findings could provide insights into new therapeutic targets for improving patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pancreatic ductal adenocarcinoma or those at high risk for developing this type of cancer.
Not a fit: Patients with other types of cancer or those without pancreatic cancer risk factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that target the cellular interactions involved in pancreatic cancer, potentially improving survival rates.
How similar studies have performed: Other research has shown promise in targeting cancer-associated fibroblasts in various cancers, suggesting that this approach may yield valuable insights for pancreatic cancer as well.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Bischoff, Allison — University of Michigan at Ann Arbor
- Study coordinator: Bischoff, Allison
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.