Investigating how certain cells contribute to inflammation in rheumatoid arthritis and lupus
Role of fibroblastic stromal cells and notch signaling in tissue inflammation in RA and SLE
This study is looking at how certain cells in the body contribute to inflammation in conditions like rheumatoid arthritis and lupus nephritis, with the hope that understanding these processes will help find new ways to treat these diseases.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11064784 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of specific fibroblastic stromal cells and Notch signaling in driving inflammation in conditions like rheumatoid arthritis (RA) and lupus nephritis (LN). By analyzing tissue samples, the researchers aim to identify how these cells contribute to chronic inflammation and the recruitment of immune cells. The study employs advanced techniques such as single-cell RNA sequencing to explore the cellular and molecular mechanisms involved. Patients may benefit from insights that could lead to new therapeutic targets for managing their conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with rheumatoid arthritis or lupus nephritis.
Not a fit: Patients with conditions unrelated to chronic inflammation or those without a diagnosis of RA or lupus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that more effectively manage inflammation in patients with rheumatoid arthritis and lupus.
How similar studies have performed: Previous research has shown promising results in understanding the role of fibroblasts in inflammation, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Brenner, Michael B. — Brigham and Women's Hospital
- Study coordinator: Brenner, Michael B.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.