Investigating how certain cell transitions affect atherosclerotic plaque stability based on sex and age.
Endothelial Cell to Mesenchymal Cell Transitions Play a Critical Biological Sex- and Aging-Dependent Role in Formation and Maintenance of the Acta2+ Atherosclerotic Lesion Protective Fibrous Cap
This study is looking at how certain cells in the blood vessels change and help keep heart plaque stable, and it aims to understand how age and gender affect this process, which could lead to better ways to prevent heart attacks and strokes for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11002021 on NIH RePORTER |
What this research studies
This research explores the role of endothelial cells transitioning into mesenchymal cells in the formation and maintenance of protective fibrous caps on atherosclerotic lesions. By studying these processes in animal models, the research aims to understand how biological sex and aging influence plaque stability, which is crucial for preventing heart attacks and strokes. The methodology includes genetic modifications and dietary interventions to observe changes in plaque characteristics over time. Patients may benefit from insights that could lead to new treatments or preventive strategies for atherosclerosis.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals at risk for atherosclerosis, particularly those with a family history of cardiovascular disease, and those experiencing age-related vascular changes.
Not a fit: Patients with established atherosclerotic disease who are not at risk for plaque instability may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing heart attacks and strokes by enhancing the stability of atherosclerotic plaques.
How similar studies have performed: Previous research has shown promising results in understanding cell transitions in atherosclerosis, indicating that this approach may yield valuable insights.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Owens, Gary K — University of Virginia
- Study coordinator: Owens, Gary K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.