Investigating how certain cell surface receptors help the hepatitis B virus infect cells
Cell surface receptors promoting hepatitis B virus infection
['FUNDING_R01'] · WAKE FOREST UNIVERSITY HEALTH SCIENCES · NIH-10835910
This study is looking at how the hepatitis B virus gets into human cells and is especially interested in a protein called apoE that helps the virus infect cells, with the goal of finding new ways to treat chronic hepatitis B.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WAKE FOREST UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (WINSTON-SALEM, UNITED STATES) |
| Trial ID | NIH-10835910 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the mechanisms by which the hepatitis B virus (HBV) infects human cells, particularly through the role of specific cell surface receptors. The team has developed a robust cell culture system to study HBV propagation and has identified human apolipoprotein E (apoE) as a key factor that enhances HBV infection. By exploring these interactions, the research aims to identify new antiviral strategies that could lead to more effective treatments for chronic HBV infection. The methodology includes advanced techniques such as CRISPR to manipulate genes involved in the infection process.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are chronically infected with hepatitis B virus and are seeking new treatment options.
Not a fit: Patients who have cleared the hepatitis B virus or those who are not infected will not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antiviral therapies that effectively cure chronic hepatitis B infection.
How similar studies have performed: Other research has shown promise in targeting viral entry mechanisms, suggesting that this approach could lead to significant advancements in hepatitis B treatment.
Where this research is happening
WINSTON-SALEM, UNITED STATES
- WAKE FOREST UNIVERSITY HEALTH SCIENCES — WINSTON-SALEM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LUO, GUANGXIANG GEORGE — WAKE FOREST UNIVERSITY HEALTH SCIENCES
- Study coordinator: LUO, GUANGXIANG GEORGE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.