Investigating how certain cell death processes affect cancer treatment resistance
Molecular Imaging Core
This study is looking at how a special kind of cell death affects esophageal cancer cells and their ability to resist radiation treatment, using advanced imaging techniques to find better ways to help patients respond to therapy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10917378 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of ferroptosis, a specific type of cell death, in how esophageal adenocarcinoma cells develop resistance to radiation therapy. The Molecular Imaging Core at the University of Texas MD Anderson Cancer Center will utilize advanced imaging techniques, such as positron emission tomography (PET) and bioluminescence imaging, to study these processes in preclinical models. By collaborating with various research projects, the core aims to develop precise imaging protocols that can help identify the biological mechanisms behind treatment resistance. This work could lead to improved strategies for overcoming resistance in cancer therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with esophageal adenocarcinoma who are undergoing or considering radiation therapy.
Not a fit: Patients with other types of cancer or those not receiving radiation therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with esophageal adenocarcinoma by overcoming resistance to radiation therapy.
How similar studies have performed: Previous research has shown promise in using imaging techniques to study cancer treatment resistance, indicating that this approach could yield valuable insights.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Piwnica-Worms, David — University of Tx Md Anderson Can Ctr
- Study coordinator: Piwnica-Worms, David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.