Investigating how certain cancer cells survive treatment in colorectal cancer
Targeting regenerative reprogramming in colorectal cancer
This study is looking at how some colorectal cancer cells manage to survive treatment and keep growing, with the hope of finding new ways to stop these tough cells for patients who need better options.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11162104 on NIH RePORTER |
What this research studies
This research focuses on understanding how some colorectal cancer cells can evade treatment and continue to grow. By using advanced sequencing techniques, the study aims to identify specific characteristics of these resistant cells and how they activate regenerative programs that help them survive. The researchers will analyze patient-derived organoids and utilize single-cell technologies to trace the origins of these resistant cells. The ultimate goal is to find new therapeutic targets that can effectively combat these treatment-resistant tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with colorectal cancer who have experienced treatment resistance.
Not a fit: Patients with early-stage colorectal cancer who have not yet undergone treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively target and eliminate treatment-resistant colorectal cancer cells.
How similar studies have performed: Other research has shown promise in targeting regenerative mechanisms in cancer, suggesting that this approach could be effective.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Alonso Martinez, Salvador — University of Tx Md Anderson Can Ctr
- Study coordinator: Alonso Martinez, Salvador
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.