Investigating how certain cancer cells resist radiation therapy
Administrative Core
This study is looking at how esophageal and lung cancer cells become resistant to radiation therapy and aims to find ways to make these cancer cells more vulnerable to treatment by exploring a special type of cell death called ferroptosis, which could help improve outcomes for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10917377 on NIH RePORTER |
What this research studies
This research focuses on understanding how esophageal and lung cancer cells develop resistance to radiation therapy, a common treatment for these cancers. The project will explore the role of a process called ferroptosis, which is a type of cell death, and how it can be manipulated to enhance the effectiveness of radiation treatment. By examining the mechanisms behind this resistance, the research aims to identify new strategies to make cancer cells more susceptible to radiation therapy, potentially improving treatment outcomes for patients. The study will involve advanced imaging techniques to monitor tumor responses and the effects of combining ferroptosis inducers with radiation therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with esophageal adenocarcinoma or lung cancer who are undergoing radiation therapy.
Not a fit: Patients with cancers other than esophageal or lung cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved radiation therapy outcomes for patients with esophageal and lung cancers.
How similar studies have performed: Previous research has shown promising results in manipulating cell death pathways to enhance cancer treatment, indicating potential for success in this approach.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Gan, Boyi — University of Tx Md Anderson Can Ctr
- Study coordinator: Gan, Boyi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.