Investigating how certain cancer cells change in oral cavity squamous cell carcinoma

Who could benefit from this research

What this research studies

This research focuses on understanding the behavior of oral cavity squamous cell carcinoma (OSCC) cells, particularly how they undergo a process called partial epithelial-to-mesenchymal transition (p-EMT). By using advanced three-dimensional organoid models derived from patient tissues, the study aims to explore how specific signals from surrounding cells influence cancer cell characteristics and treatment responses. The researchers will analyze the interactions between cancer cells and cancer-associated fibroblasts to identify potential new therapeutic targets. This approach seeks to improve patient stratification and the development of targeted treatments for OSCC.

Why it matters

Where this research is happening

• Columbia University Health Sciences
  New York, United States Active

Researchers

• Principal investigator: Parikh, Anuraag Suhrid — Columbia University Health Sciences
• Study coordinator: Parikh, Anuraag Suhrid

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.