Investigating how certain brain signals affect metabolism and obesity.
Alpha2/delta1- thrombospondin-3 signaling in the central control of metabolic function
['FUNDING_R01'] · TUFTS UNIVERSITY BOSTON · NIH-11058412
This study is looking at how a special protein in the brain affects our energy and sugar levels, and how problems with this protein might lead to overeating and obesity, with the goal of finding new ways to help manage weight and related health issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TUFTS UNIVERSITY BOSTON (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11058412 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of brain-derived neurotrophic factor (BDNF) and its receptor in regulating energy and glucose levels in the body. It examines how deficits in these signals can lead to overeating and obesity, using animal models to explore the effects of specific receptors in the brain. The study aims to identify potential therapeutic targets that could help manage obesity and related metabolic disorders by restoring normal signaling pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults experiencing obesity or metabolic dysfunction, particularly those with a history of overeating.
Not a fit: Patients who are not overweight or do not have metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for obesity and metabolic disorders by targeting specific brain signaling pathways.
How similar studies have performed: Previous research has shown promising results in targeting similar brain signaling pathways to improve metabolic health, indicating potential for success in this approach.
Where this research is happening
BOSTON, UNITED STATES
- TUFTS UNIVERSITY BOSTON — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RIOS, MARIBEL — TUFTS UNIVERSITY BOSTON
- Study coordinator: RIOS, MARIBEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.