Investigating how certain brain receptors affect memory formation and stability
Official title: CRCNS: Role of mAChRs on CA 1 pyramidal neurons in memory formation and stability
Funded at Max Planck Florida Corporation · NIH-10907042 · Data updated 2026-11-12
This study is looking at how certain brain receptors affect memory, especially as we age or in people with Alzheimer's, to help us understand why memory problems happen and find ways to improve them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Max Planck Florida Corporation NIH-funded |
| Lab location | 1 site (Jupiter, UNITED STATES) |
| Project start | August 15, 2023 |
| Project end | April 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $334,693 |
| NIH project number | 5R01AG085899-02 |
| Project ID | NIH-10907042 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing memory issues related to aging or Alzheimer's disease.
✕Less likely to help
Patients with memory issues not related to cholinergic dysfunction or those with other forms of dementia may not benefit from this research.
What this research studies
This research focuses on understanding the role of muscarinic acetylcholine receptors in the hippocampus, a brain region essential for memory. By studying these receptors on specific neurons, the research aims to uncover how cholinergic modulation influences memory formation and retention, particularly in the context of aging and Alzheimer's disease. The approach involves manipulating neuronal activity and observing the effects on memory-related patterns during tasks. This could provide insights into the underlying mechanisms of memory impairment in Alzheimer's patients.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving memory function in patients with Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding cholinergic modulation in memory, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Max Planck Florida Corporation
Jupiter, United States Active
Researchers
- Principal investigator: Wang, Yingxue — Max Planck Florida Corporation
- Study coordinator: Wang, Yingxue
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.