Investigating how certain brain receptors affect cognitive issues in Parkinson's disease

Who could benefit from this research

What this research studies

This research explores the role of α4β2 nicotinic cholinergic receptors in the brain and their connection to cognitive impairment in Parkinson's disease (PD). By using advanced imaging techniques and cognitive testing, the study aims to understand how changes in these receptors contribute to abnormal brain oscillations that affect cognitive functions. The research combines molecular imaging with intracranial recordings to gather detailed data on brain activity and receptor signaling. This approach may help identify new treatment targets for cognitive deficits in PD.

Why it matters

Where this research is happening

• Johns Hopkins University
  Baltimore, United States Active

Researchers

• Principal investigator: Mills, Kelly Alexander — Johns Hopkins University
• Study coordinator: Mills, Kelly Alexander

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.