Investigating how certain brain receptors affect cognitive issues in Parkinson's disease
The role of cortical nicotinic receptors in pathological brain oscillations in Parkinson's disease cognitive impairment
This study is looking at how certain brain receptors might be linked to thinking problems in people with Parkinson's disease, using special imaging and tests to better understand these connections and find new ways to help improve memory and thinking skills.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10774326 on NIH RePORTER |
What this research studies
This research explores the role of α4β2 nicotinic cholinergic receptors in the brain and their connection to cognitive impairment in Parkinson's disease (PD). By using advanced imaging techniques and cognitive testing, the study aims to understand how changes in these receptors contribute to abnormal brain oscillations that affect cognitive functions. The research combines molecular imaging with intracranial recordings to gather detailed data on brain activity and receptor signaling. This approach may help identify new treatment targets for cognitive deficits in PD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease who are experiencing cognitive impairment.
Not a fit: Patients with Parkinson's disease who do not exhibit cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cognitive impairment in patients with Parkinson's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of nicotinic receptors in cognitive functions, suggesting that this approach may yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Mills, Kelly Alexander — Johns Hopkins University
- Study coordinator: Mills, Kelly Alexander
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.